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Department of Cell Pathology


  1. Mrówczyńska E., Mazur A.J. Integrin-Linked Kinase (ILK) Plays an Important Role in the Laminin-Dependent Development of Dorsal Root Ganglia during Chicken Embryogenesis. Cells. 2021 Jul 2;10(7):1666
  2. Erdmann C., Hassoun R., Schmitt S., Kikuti C., Houdusse A., Mazur A.J., MüggeA., Hamdani N., Geyer M., Jaquet K., Mannherz H.G. (2021) Integration of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G) into Cellular Structures. Antioxidants (Basel). 2021 5;10(7):1082
  3. Makowiecka A., Mazurkiewicz E., Mrówczyńska E., Malek N., Battistella A., Lazzarino M., Nowak D., Mazur A. J. (2021) Changes in Biomechanical Properties of A375 Cells Due to the Silencing of TMSB4X Expression Are Not Directly Correlated with Alterations in Their Stemness Features. Cells. 2021 Mar 31;10(4):769
  4. Dratkiewicz E., Simiczyjew A., Mazurkiewicz J., Ziętek M., Matkowski R., Nowak D. (2021) Hypoxia and Extracellular Acidification as Drivers of Melanoma Progression and Drug Resistance. Cells. 2021, 10(4), 862
  5. Mazurkiewicz E., Mrówczyńska E., Simiczyjew A., Nowak D., Mazur A. J. (2021) A Fluorescent Gelatin Degradation Assay to Study Melanoma Breakdown of Extracellular Matrix. Methods Mol Biol. 2021;2265:47-63
  6. Malek N., Michrowska A., Mazurkiewicz E., Mrówczyńska E., Mackiewicz P., Mazur A. J. (2021) The origin of the expressed retrotransposed gene ACTBL2 and its influence on human melanoma cells’ motility and focal adhesion formation. Sci Rep. 2021 Feb 8;11(1):3329
  7. Kupczyk P., Simiczyjew A., Marczuk J., Dratkiewicz E., Beberok A., Rok J., Pieniazek M., Biecek P., Nevozhay D., Slowikowski B., Chodaczek G., Wrzesniok D., Nowak D., Donizy P. (2021) PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study. Cells. 2021 Jan 31;10(2):286
  8. Podgórska M., Pietraszek-Gremplewicz K., Olszańska J., Nowak D. (2021) The Role of Apelin and Apelin Receptor Expression in Migration and Invasiveness of Colon Cancer Cells. Anticancer Res. Jan 2021 41 (1) 151-161
  9. Mazurkiewicz J., Simiczyjew A., Dratkiewicz E., Ziętek M., Matkowski R., Nowak D. (2021) Stromal Cells Present in the Melanoma Niche Affect Tumor Invasiveness and Its Resistance to Therapy. Int J Mol Sci. 2021, 22(2), 529
  10. Simiczyjew A., Dratkiewicz E., Mazurkiewicz J., Ziętek M., Matkowski R., Nowak D. (2020) The Influence of Tumor Microenvironment on Immune Escape of Melanoma. Int J Mol Sci. 2020 Nov 7;21(21):E8359
  11. Malek N, Mrówczyńska E, Michrowska A, Mazurkiewicz E, Pavlyk I, Mazur AJ. (2020) Knockout of ACTB and ACTG1 With CRISPR/Cas9(D10A) Technique Shows That Non-Muscle β and γ Actin Are Not Equal in Relation to Human Melanoma Cells’ Motility and Focal Adhesion Formation. Int J Mol Sci. 2020 Apr 15;21(8):2746
  12. Dratkiewicz E., Simiczyjew A., Pietraszek-Gremplewicz K., Mazurkiewicz J., Nowak D. (2019) Characterization of Melanoma Cell Lines Resistant to Vemurafenib and Evaluation of Their Responsiveness to EGFR- and MET-Inhibitor Treatment. Int J Mol Sci. 2019 Dec 23;21(1)
  13. Pietraszek-Gremplewicz K., Simiczyjew A., Dratkiewicz E., Podgórska M., Styczeń I., Matkowski R., Ziętek M., Nowak D. (2019) Expression level of EGFR and MET receptors regulates invasiveness of melanoma cells. J Cell Mol Med. 2019 Dec;23(12):8453-8463
  14. Makowiecka A., Malek N., Mazurkiewicz E., Mrówczyńska E., Nowak D., Mazur AJ. (2019) Thymosin β4 Regulates Focal Adhesion Formation in Human Melanoma Cells and Affects Their Migration and Invasion. Front Cell Dev Biol. 2019 Dec 23;7:304
  15. Simiczyjew A., Pietraszek-Gremplewicz K., Dratkiewicz E., Podgórska M., Matkowski R., Ziętek M., Nowak D. (2019) Combination of Selected MET and EGFR Inhibitors Decreases Melanoma Cells’ Invasive Abilities. Front Pharmacol. 2019 Oct 1;10:1116
  16. Podgórska M., Diakowska D., Pietraszek-Gremplewicz K., Nienartowicz M., Nowak D. (2019) Evaluation of Apelin and Apelin Receptor Level in the Primary Tumor and Serum of Colorectal Cancer Patients. J Clin Med. 2019 Sep 20;8(10)
  17. Simiczyjew A., Dratkiewicz E., Van Troys M., Ampe C., Styczeń I., Nowak D. (2018) Combination of EGFR Inhibitor Lapatinib and MET Inhibitor Foretinib Inhibits Migration of Triple Negative Breast Cancer Cell Lines. Cancers (Basel); 2018 Sep 17;10(9).
  18. Podgórska M., Pietraszek-Gremplewicz K., Nowak D. (2018) Apelin Effects Migration and Invasion Abilities of Colon Cancer Cells. Cells; 2018 Aug 20;7(8).
  19. Wysocka M.B., Pietraszek-Gremplewicz K., Nowak D. (2018) The role of apelin in cardiovascular diseases, obesity and cancer. Front Physiol; 9:557
  20. Dratkiewicz E., Pietraszek-Gremplewicz K., Simiczyjew A., Mazur A.J., Nowak D. (2018) Gefitinib or lapatinib with foretinib synergistically induce a cytotoxic effect in melanoma cell lines. Oncotarget; 9:18254-18268.
  21. Simiczyjew A., Pietraszek-Gremplewicz K., Mazur A.J., Nowak D. (2017) Are non-muscle actin isoforms functionally equivalent? Histol Histopathol; 32(11):1125-1139.
  22. Simiczyjew A., Mazur A.J., Dratkiewicz E., Nowak D. (2017) Involvement of β- and γ-actin isoforms in actin cytoskeleton organization and migration abilities of bleb-forming human colon cancer cells. PLoS One; 23;12(3).
  23. Masuzzo P., Huyck L., Simiczyjew A., Ampe C., Martens L., Van Troys M. (2017) An end-to-end software solution for the analysis of high-throughput single-cell migration data. Sci Rep; 7:42383
  24. Makowiecka A., Simiczyjew A., Nowak D., Mazur A.J. (2016) Varying effects of EGF, HGF and TGFβ on formation of invadopodia and invasiveness of melanoma cell lines of different origin. Eur J Histochem; 60(4):2728.
  25. Baczynska D., Bombik I., Malicka-Błaszkiewicz M. (2016) β-Catenin Expression Regulates Cell Migration of Human Colonic Adenocarcinoma Cells Through Gelsolin. Anticancer Res; 36(10):5249-5256.
  26. Mazur A.J., Radaszkiewicz T., Makowiecka A., Malicka-Błaszkiewicz M., Mannherz H.G., Nowak D. (2016) Gelsolin interacts with LamR, hnRNP U, nestin, Arp3 and β-tubulin in human melanoma cells as revealed by immunoprecipitation and mass spectrometry. Eur J Cell Biol; 95(1):26-41.
  27. Simiczyjew A., Mazur AJ., Ampe C., Malicka-Błaszkiewicz M., van Troys M., Nowak D. (2015) Active invadopodia of mesenchymally migrating cancer cells contain both β and γ cytoplasmic actin isoforms. Exp Cell Res; 339(2):206-19.
  28. Migocka-Patrzałek M., Makowiecka A., Nowak D., Mazur A.J., Hofmann W.A., Malicka-Błaszkiewicz M. (2015) β- and γ-Actins in the nucleus of human melanoma A375 cells. Histochem Cell Biol; 144(5):417-28.
  29. Mazur A.J., Morosan-Puopolo G., Makowiecka A., Malicka-Błaszkiewicz M., Nowak D.  and Brand-Saberi B. (2014) Analysis of gelsolin expression pattern in developing chicken embryo reveals high GSN expression level in tissues of neural crest origin. Brain Structure & Function DOI: 10.1007/s00429-014-0923-5.
  30. Al Haj, A., Mazur, A. J., Radaszkiewicz, K., Radaszkiewicz, T., Makowiecka, A., Stopschinski, B. E., Schonichen A., Geyer M. and Mannherz, H. G. (2014). Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres. European Journal of Cell Biology; 1–13. doi:10.1016/j.ejcb.2014.11.003
  31. Simiczyjew A., Mazur A.J., Popow-Woźniak A., Malicka-Błaszkiewicz M., Nowak D. (2014) Effect of overexpression of β- and γ-actin  isoforms  on actin cytoskeleton organization and migration of human colon cancer cells. Histochem Cell Biology; 2014 142(3):307-322.
  32. Al Haj, A., Mazur, A. J., Buchmeier, S., App, C., Theiss, C., Silvan, U., Schoenenberger C. Jousch B. M., Hannappel E., Weeds A.G and Mannherz, H. G. (2014). Thymosin beta4 inhibits ADF/cofilin stimulated F-actin cycling and hela cell migration: Reversal by active Arp2/3 complex. Cytoskeleton (Hoboken, N.J.); 71 Issue 2, 95-107.
  33. Chełmońska-Soyta A., Ozgo M., Lepczynski A., Herosimczyk A., Buska K., Kedzierska A., Nowak D., Mazur A. (2014) Proteome of spleen CD4 lymphocytes in mouse preimplantation pregnancy, Journal of Physiology and Pharmacology; 65,5, 719-731.
  34. Simiczyjew A., Malicka-Błaszkiewicz M., Nowak D. (2013) Funkcjonalne zróżnicowanie cytoplazmatycznych izoform aktyny. Postępy Biochemii; 59, 285-294.
  35. Schonichen A., Mannherz H.G., Behrmann E., Mazur A.J., Kuhn S., Silvan U., Schoenenberger C.A., Fackler O.T., Raunser S., Dehmelt L., Geyer M. (2013) FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibres.  Journal of Cell Science; 126: 1891-1901
  36. Litwin M, Nowak D, Mazur AJ,  Baczyńska D, Mannherz HG., Malicka-Blaszkiewicz M (2012) Gelsolin affects the migratory ability of human colon adenocarcinoma and melanoma cells  Life Sci  90, 851-61.
  37. Popow-Woźniak A, Mazur AJ, Mannherz HG., Malicka-Błaszkiewicz M., Nowak D. (2012) Cofilin overexpression affects actin cytoskeleton organization and migration of human colon adenocarcinoma cells – Histochem Cell Biology; 138, 725-736.
  38. Radwanska A, Litwin M, Nowak  D, BaczynskaD, Wegrowski Y, Maquart FX, Malicka-Błaszkiewicz M (2012) Overexpression of lumican affects the migration of human colon cancer cells through up-regulation of gelsolin and filamentous actin reorganization. Exp Cell Res; 318, 2312-2323
  39. Müller M.*, Mazur A.J.*, Behrmann E., Diensthuber R.P., Radke M.B., Qu Z., Littwitz C., Raunser S., Schoenenberger C.A., Manstein D.J., Mannherz H.G. (2012) „Functional characterization of the human α-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy”. Cell Mol Life Sci., 69, 3457-79, *-both authors equally contributed to the work
  40. Bechara, F.G., Mannherz, H.G., Jacob, M., Mazur A.J., Sand, M.,  Altmeyer, P., Hoffmann, K.(2012) “Induction of fat cell necrosis in human fat tissue after treatment with phosphatidylcholine and deoxycholate.” Journal of the European Academy of Dermatology and Venereology 26, 180-185,
  41. Popow-Woźniak A.,,WoźniakowskaA.,, Kaczmarek Ł., Malicka-Błaszkiewicz M., Nowak D (2011)Apoptotic effect of imatinib on human colon adenocarcinoma cells: influence on actin cytoskeleton organization and cells migration. Eur.J. Pharmacol., 667, 66-73.
  42. Nowak D, Mazur A, Popow-Woźniak A., Radwańska A.,Mannherz H.G, Malicka-Błaszkiewicz M (2010)Subcellular distribution and expression of cofilin and ezrin in human colon adenocarcinoma cell lines with different metastatic potential. Eur J Histochem, 54(2), 59-66.
  43. Machaidze, G., Sokoll, A., Shimada, A., Lustig, A., Mazur, A.J., Wittinghofer, A., Aebi, U., Mannherz H.G. “Actin Filament Bundling and Different Nucleating Effects of Mouse Diaphanous-Related Formin FH2 Domains on Actin:ADF and Actin:Cofilin Complexes”. Journal of Molecular Biology 403, 529-45, 2010
  44. Mannherz, H.G., Mazur, A.J., Jockusch, B. “Repolymerisation of Actin from Actin:Thymosin beta 4 complex induced by diaphanous related formins and gelsolin”. Annals of the New York Academy of Sciences 1194, 36-43, 2010
    Mazur, A.J., Gremm, D., Dansranjavin, T., Litwin, M., Jockusch, B.M., Wegner, A., Weeds, A.G., Mannherz, H.G.: Modulation of actin filament dynamics by actin binding proteins residing in lamellipodia. European Journal of Cell Biology 89, 402-413, 2010.
  45. Litwin M., Mazur A.J, Nowak D., Mannherz H.G, Malicka-Błaszkiewicz M. (2009) Gelsolin In human colon adenocarcinoma cells with different metastatic potential. Acta Biochim. Polon, 56(4), 739-743.
  46. Mazur A.,  Nowak D., Mannherz H.G, Malicka-BłaszkiewiczM.(2009) Apoptotic effect of methotexate on CaSki and NRK cells – influence on actin cytoskeleton organization , Eur.J. Pharmacol.
  47. Popow-Woźniak A, Nowak D., Malicka-Błaszkiewicz M.(2009) Sposoby migracji komórek nowotworowych. Postępy Biochemii, 55(2), 113-120.
  48. Nowak .D,  Popow-Woźniak A,Raźnikiewicz L., Malicka-Błaszkiewicz M. (2009) Aktyna w procesie gojenia ran. Postępy Biochemii, 55(2), 138-144.
  49. Mannherz H.G., Mach M.,  Mazur A., Nowak D., Malicka-Błaszkiewicz M. (2008) Lamellipodial and ameboid cell locomotion: the role of actin-cycling and bleb formation. Biophys. Rev. Lett., 2, no 1, 1-18.
  50. Radwanska A., Baczynska D., Nowak D., Brezillon S., Popow A., Macquart F.X., Wegrowski Y, Malicka-Błaszkiewicz M. (2008) Lumican affects actin cytoskeletal organization in human melanoma A375 cells. Life Sciences, 83, 651-660.
  51. Theiss, C., Mazur A., Meller K., Mannherz H.G. (2007) Changes in gap junction organization and decreased coupling during induced apoptosis in lens epithelial and NIH-3T3 cells. Experimental Cell Research 313, 28-52.
  52. Popow A., Nowak D., Malicka-Błaszkiewicz M (2006) Actin cytoskeleton and beta-actin expression in correlation with higher invassiveness of selected hepatoma Morris 5123 cells; J. Physiol. Pharmacol., 57, 111-124.
  53. Nowak D., Skwarek-Maruszewska A., Zemanek-Zboch M., Malicka-Błaszkiewicz M. (2005) Beta actin in human colon adenocarcinoma cells with different metastatic potential. Acta Biochim. Polon. 52, 461-468. 1,6 IF;
  54. Osińska-Królicka I., Podsiadły H., Bukietyńska K., Zemanek-Zboch M., Nowak D., Suchoszek-Łukaniuk K.,  Malicka-Błaszkiewicz M. (2004) Vanadium(III) complexes with L-Cysteine – stability, speciation and the effect on actin in hepatoma Morris 5123 cells. J. Inorg.Biochem., 98, 2087-2098. 3.5 IF; 32pkt
  55. Nowak D., Krawczenko A., Duś D., Malicka-Błaszkiewicz M.(2002) Actin in human colon adenocarcinoma cells with different metastatic potential. Acta Biochim. Polon. 4, 823-828.
  56. Nowak D., Malicka-Błaszkiewicz M., (1999) Izoformy aktyny – zróżnicowanie funkcji, zmiany w stanach patologicznych. Postępy Biochemii 45 (4): 261-269.