Dr. Jonathan S. Harrison, Associate Professor of Medicine, Division of Hematology, Dept. of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey

Talk will include:

• Overview of the diseases AML and MDS.
• Pre-clinical (tissue culture and animal model data) that indicate that pharmacologic doses of Vitamin D or its analogs (deltanoids), with or without potentiating agents such as carnosic acid, or MAP Kinase pathway inhibitors, can differentiate myeloid leukemia cells.
• The review of the clinical trial data to data, and suggest the structure of future clinical trials using deltanoids.