Zapraszamy wszystkich pracowników i studentów na seminarium wydziałowe, podczas którego odbędzie się wykład gościnny w ramach Programu przyjazdów profesorów wizytujących (wizyty krótkie), będącego jednym z działań projektu „Inicjatywa Doskonałości – Uczelnia Badawcza”.
Gościem na naszym Wydziale będzie Robert Zarnowski, PhD (University of Wisconsin-Madison, USA) , który – na zaproszenie dr Anny Jaromin z Zakładu Lipidów i Liposomów – wygłosi wykład otwarty pt. „Pathogenicity determinants of Candida biofilm biology”.
Wykład odbędzie się 25 marca 2025 r. w godzinach 13.00-14.30 w budynku Wydziału Biotechnologii, w auli 1.05.
Wizyta finansowana ze środków programu „Inicjatywa Doskonałości – Uczelnia Badawcza”.
Extracellular matrix deposits in Candida albicans biofilm.
Tematyka wykładu:
Fungi are responsible for an estimated 2.5 million deaths annually, with Candida species ranking among the leading causes of invasive fungal disease. Candida albicans remains the most common cause of Candida infections, while Candida auris has recently emerged as a globally significant, multidrug-resistant, health care-associated fungal pathogen. Mortality rates related to Candida infections often exceed 40% despite available therapeutic interventions. A major contributor to the virulence of Candida is its ability to form biofilms, which exhibit enhanced pathogenicity driven by several key determinants. Among these is the production of an extracellular matrix (ECM) that shields fungal cells from antifungal agents and host immune defenses. The ECM is composed of the four major classes of biomolecules: carbohydrates, lipids, nucleic acids, and proteins. Its formation is mediated by secreted extracellular vesicles (EVs), which deliver cargo into the extracellular milieu, further strengthening biofilm resilience. As a result, Candida biofilms present a significant challenge in clinical settings. Understanding the role of EVs in Candida biofilm biology opens new avenues for drug repurposing strategies aimed at combating these often deadly fungal infections. This talk highlights the most recent findings on EV-driven pathogenicity determinants in Candida biofilms.