Zapraszamy na wykład Roberta Zarnowskiego, PhD (University of Wisconsin-Madison, USA), który odbędzie się w dniu 18.04.2023. o godz. 10.00 w auli 1.03 Wydziału Biotechnologii Uniwersytetu Wrocławskiego (ul. F. Joliot-Curie 14a). Wykład odbędzie się w ramach programu zapraszania profesorów wizytujących realizowanego (IDUB):

Exosomes in fungal biofilm biology

Robert Zarnowski, PhD
Department of Medicine (Infectious Disease Division), School of Medicine & Public Health, University of Wisconsin-Madison, Madison, USA 

Candida albicans biofilm.

Exosomes are made by all living organisms and function in highly crowded environments of fungal biofilms, which consist of microbial cells encased in a complex extracellular polymeric matrix and exhibit extreme tolerance to antimicrobial compounds. Exosomes in Candida albicans biofilms are produced via the endosomal sorting complexes required for transport (ESCRT) system and regulate biofilm matrix accumulation and drug resistance by sharing of fungal community resources. The exosomal cargo proteins often fulfill pivotal roles in two or more of the biofilm biology phases, including fungal cell adhesion and mature biofilm dissemination. Exosomes do not only coordinate cell-to cell interactions in monospecies biofilms, but also regulate crosstalk between diverse Candida species using a set of conserved cargo proteins. While these exosomes are required for biofilm maturation features, including matrix production, drug resistance, and dispersion, their role in early polymicrobial biofilms delineates more competitive interferences. This talk outlines our recent findings related to Candida biofilm exosomes, their cargo, and both cooperative and competitive functionality roles among Candida species, depending on the needs of the community biofilm biology.